Breath-based stratification of asthma severity using the MISTRAL platform with integrated H2S sensor and clinical validation

Germinario, Raffaella; Andriani, E.; Tondo, Pasquale; Soccio, Piera; la Grasta, Annabella; Cafagna, Isabella; Lacedonia, Donato; Dell’Olio, Francesco; Scioscia, Giulia.(2026) Scientific Reports
Exhaled breath analysis offers a painless window into airway inflammation, yet its clinical adoption is
limited by a shortage of robust biomarkers. Hydrogen sulfide (H2S) has been detected in biological
fluids, but its diagnostic value across asthma severities is not well established. In this study,
we integrated an electrochemical H2S sensor with a detection limit of 1 ppb into the MISTRAL
platform. We evaluated exhaled H2S in a prospective cohort of 28 adult asthmatic patients. Mean
exhaled H2S concentrations were…
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